Because of skin integrity issues in the neonate, PICC line dressing changes should be performed after the 1st 24 hours, and then prn thereafter. After the initial PICC insertion, there may be some bloody drainage on the dressing, which needs to be changed to prevent bacterial growth. A clear transparent dressing may replace the initial dressing and remain in place unless soiled or dressing integrity is compromised. The site must also be assessed for signs of infection as well. Constant removal of these occlusive dressings can wear havoc on delicate neonatal skin, creating irritation, skin shearing/stripping, and another port of entry for infection.