I have 2 cats I travel with all over the country. THey do very well in their carriers. I usually let them out in the bathroom of the hotel I will be staying at that night first to do their business. I find that Daphne usually gets a little too wise about the routine though. She has held me up a couple times in the hotel for a little longer then I would like in the morning. Both kitties settle right down after a few minutes on the road.