I work for a Dr. who treats a lot of Lyme patients. For some patients, the Dr. has prescribed IM Bicillin LA, in weekly doses. Usually the dose is 1.2M units, but for others, the Dr. has increased the dose to 2.4M units per week. The Dr. prefers that the the 2.4M dose is given in a single injection, all in one buttock. His reasoning is that while it is a large injection, it is easier on the patient overall rather than splitting into two sites, since the injections can be alternated between buttocks every other week. The manufacter supplies the 2.4M Bicillin dose in a 4cc volume, and a disposable syringe with an 18g 2 inch needle. Adminstering this volume with this needle has been a pretty uncomfortable experience for most of my patients. Does anyone have experience with the 2.4M dose vs. splitting the dose into two sites? Thanks.