We have a couple of patients that are extremly non compliant and bring in 7 - 8 kg of weight on a regular basis. They cramp every single treatment and there is nothing we can do about it. If we leave the fluid on them we risk CHF and other nasty things that go along with it. Now that being said the fluid shift will happen at different rates for different people, when someone has this much fluid on we see it happen on the machine where someone with only 3 kg on might not see it till sometime after treatment. Also, being diabetic will effect the rate fluid will shift. Our clinic uses a drug called Mannitol, this is a high powered diuretic. It helps the fluid shift that is happening from the tissue to the blood. We generally use this on patients that show signs of edema, periorbital and in the extremities. If a patient is having difficulty maintaining a BP and is 1 - 2 hours into treatment this will help out tremendously about 90% of the time. Now something to take into consideration is that Mannitol also works on the cerebral spinal fluid and actually is used to decrease intracranial pressure so there you go.