I'd suggest making a pros and cons list for each position, value each option in your list with a number, and see what the total "value" of Job A and Job B are based on how much you value the pros or how much of a "Absolutely Not!" the con is. This may help you make a more objective decision based on your own needs out of a job/career and whether these positions align with your values. Do you mind the social impact a night-shift job will take? Do you care that you'll be on a different schedule than your friends, family, and significant other? And so on and so on. Most importantly: If you have not signed yet, you are not legally bound to work for B. Yet. Do not sign until you know for sure that you 1. did not get the job with Employer A, and 2. you are willing to work at Job B despite other opportunities. In my opinion, it would be in poor taste and show disrespect to Employer B if you were to actually sign the job acceptance letter and then switch over almost immediately to Job A, assuming that all goes well with Employer A. Employer B spent resources and time interviewing you and preparing their units for someone who they thought would be a great fit for the position and could support their patients and work with their teams. Just something to think about. Good luck! :)