you metioned that small catherter is more preferred for irritating medication. But when it comes to ChemoTheraphy, does it go same? As far as Im concerened, The first route of CTx is central line like Chemoport or Hickman Cath. or C-line. But sometime, CTx medication was injected via peripehral line. And at that time, facility regulations are that never given the CTx via peripehral line smaller than 22G. hmm.. I was told that bigger size cathterter prevent vein from chance of extravasation. So what rational is beneath this?. thank you for your kindness.