Help with dosage calculation

[uwa2012]

Ok guys I need some help with a few dosage cal problems.

1. The M.D. orders "Drug F" 225 mg po q6h for an infant weighing 21 pounds. The pediatric handbook states the maximum daily dosage for an infant is 25-50 mg/kg/hr divided by 6h. Is the dosage ordered safe??

2. The label on a vial of "Drug B" indicates there are 25mg per 1 ml. Calculate the number of ml a child weighing 84 pounds would receive if the adult dose is 125mg.

3. The usual adult dose of "Drug D" is 375mg/day po. Available is "Drug D" 225mg/4ml. How many ml would be safe for a child with a BSA of .9m?

[Jonathank]

#1:

21 lbs = 9.5 kg

9.5 x 50 = 475 mg/6 hr is the maximum of the range for infant of this weight.

225 mg q6h is well within the safe range.

2 & 3: I have no ped meds training, so I don't know if there are standard infant-to-adult conversion factors, or if it varies by facility/program policy.

[Corlee]

OK...so correct me if I am wrong...but I think the answer to #1 is not a safe dose.

They said it was 25-50mg/kg/hr (I think this hour should actually be per day) divided into 4 doses (q6h)

21 Lbs = 9.5 kg

50mg(50kg)=475mg (per day)

475mg/4(divided doses) = 118.8mg Q6H is the max per dose.

I am pretty sure sure we need more info to answer questions 2 &3. Just my thoughts... :-):)

[Jonathank]

OK...so correct me if I am wrong...but I think the answer to #1 is not a safe dose.

They said it was 25-50mg/kg/hr (I think this hour should actually be per day) divided into 4 doses (q6h)

21 Lbs = 9.5 kg

50mg(50kg)=475mg (per day)

475mg/4(divided doses) = 118.8mg Q6H is the max per dose.

I am pretty sure sure we need more info to answer questions 2 &3. Just my thoughts... :-):)

The OP seems to be long gone. The wording of the post is ambiguous. Unless the OP shows up to clarify, maybe we should let this thread die quietly with dignity.