Quote from JAHJF
Never seen toradol used but Indomethacin is an NSAID used b/c it inhibits protaglandin synthesis and can be given to premies to help close a PDA?
I took Indocin during both of my pregnancies for treatment of resistant PTL. For me, it was used in addition to terbutaline, in an effort to avoid MgSO4 therapy. Hard to tell whether or not it was effective, as it caused a significant reduction in amniotic fluid volume, and had to be discontinued. Prostaglandins are believed to play a role in the onset of labor, so inhibiting prostaglandin production is the goal of Indocin. I suspect that Toradol must work in a similar manner.
Yes, Indocin is used in the treatment of infants with PDAs. Prostaglandins in the infant keep the ductus open, so inhibiting prostaglandins in these babies is an effective way of bringing about its closure.
To avoid risk of premature closure of the ductus in utero, Indocin is not used to treat PTL past a certain point in gestation (somewhere around 31-34 weeks).