FDA Panel Votes to Eliminate Vicodin and Percocet - page 12

"Government experts say prescription drugs like Vicodin and Percocet that combine a popular painkiller with stronger narcotics should be eliminated because of their role in deadly overdoses. A Food... Read More

  1. by   psalm
    Quote from hypocaffeinemia
    The reason darvocet in particular is a crappy drug is because research shows that there is no pain relief above placebo (propoxyphene-only) or above the acetaminophen in it (darvocet), yet it contains many of the typical opioid side effects and risks.
    Well, it works for me when I have a root canal or horrid perforated eardrum & infection.
  2. by   hypocaffeinemia
    Quote from psalm
    Well, it works for me when I have a root canal or horrid perforated eardrum & infection.
    No one denies the potency of placebo.
  3. by   sethmctenn
    We don't have to relearn to make the wheel. In the UK it was banned. Propoxyphene releated deaths dropped of course. There was a cooresponding increase in deaths with other opiods. In the journal Rheumatology, research by Ottenwald and Walker showed that around half of the patients who had been on propoxyphene were unable to find a suitable alternative. As for effectiveness, there are 25 million prescriptions written annually for propoxyphene products. The experience of the people taking it who feel like it works for them should be considered as well as the research. I would be in that category that would have trouble finding an alternative. Most of them are entirely too sedating for me. It's not a strong agent for pain relief but for many people it works. In the 50+ years it has been around, there have been 1400 related deaths (with suicide with multiple agents in 93% of the cases). So, if we assume that propoxyphene is the responsible agent in every one of the cases, there is a 0.0001% chance of mortality. That's better than many approved drugs. The only things we can truly know are what we experience. Everything else is hearsay. Research is hearsay we have reason to trust but if it contradicts direct experience, where do you put your trust? In people you don't know, who have their own agendas that we don't find out about most of the time? My direct experience does tell me that elderly people don't really do that great with it. I don't think it is a perfect drug but tell me about one drug that is.

    I also don't think that Lortab and Percocet should be taken off the market (getting back to the thread). We do need more, better, less addictive, less likely to create harm, pain relievers. When those come out and people can afford them, the use of more harmful pain relievers will be reduced by substitution.