Personally, I advise you transfer out here first. That way you will have one income. Since your wife just graduated, she isn't working now anyway, I assume.
1. Check for new grad residency programs or training programs for NPs. You'll have to check with every hospital in SD County and with Kaiser.
2. Have a good profile on LinkedIn. You can also set up a job alert on LinkedIn and get daily notices of new job listings.
3. Make sure the cover letter and resume clearly states will relocate at own expense, if necessary. You can tailor this - add this statement if the job listing says no relo. For a large employer, they may pay some relo for a new grad.
4. Use the usual job sites like Indeed and ZipRecruiter, etc. Also consider federal employment with the VA, Marine Corps, or Navy. The military does hire civilian NPs to work at the base hospitals. Also the federal and state prisons. County of San Diego is always looking for NPs, but they pay crappy. Although, it might be ok for a year or two just to get some experience.
5. San Diego is a popular retirement area, so consider SNFs and LTCs.
6. Again, be willing to look in the remote areas like East San Diego County. There are some Indian tribes that also occasionally have openings for NPs.
7. In California, all the postings say FNP. If your wife is AGNP, apply anyway - employers are often ok with this.
8. If you wife has not already started the California NP license process, start it ASAP! It takes 3 months to get the NP license after submitting the application. Having the California NP license makes a huge difference in a remote job search. I can't stress this enough. The licensure process in Cali is horrendously long.
9. Network, network, network. Ask friends and family in SoCal. Check with school alumni association. Use LinkedIn to network.
10. Consider South Orange County for jobs. I live in Carlsbad and have had jobs there - it is less than 1 hour commute to Newport Beach and Irvine. So look for jobs in Orange County that are Irvine and south (within 1 hour drive of North San Diego County). I have also seen some jobs that look decent in Temecula.
11. Housing is a consideration. Rents here are expensive - $2000 for a decent one BR apartment in a coastal city - cheaper if you go inland. In addition, we have an acute housing shortage, so it can be very hard to find a decent, affordable place to rent if you want to live near the coast. Good places tend to get snapped up in days.
12. Also look at the community colleges and universities for NP jobs. Even some high schools now hire NPs.