using polyurethane product since dec '99. seeing marked increase dvt.used silicone for yrs with no discernible thrombosis, dvt. watch lines closely (qd). no correlation to tip placement, cath size, pt dx, infusates, practitioner,insertion method ie micro-intro,flouro, direct. also seeing freq.retrograde leaks with the few ml's we do place.of course,use midlines sparingly with no tpn, vanco, etc.most tip placements svc- occasional subclavian when unable to thread and pt condition "permits" or demands. anyone out there seeing similar? yes, have trouble with "memory" also.those of you using coumadin prophylaxis:care to share p&p? who, when, why?