I hate having to share this story but perhaps discussing it with others will give me some respite and also others can also troubleshoot with me on what precisely went wrong. Yesterday, I lost my 81-year-old grandfather to complications from Clostridium Difficile (C-Diff) infection. Although C-diff can occasionally crop up without rhyme or reason, the vast majority of its victims are patients in hospitals or long-term care facilities -- and the great majority of them have received antibiotics (Clostridium difficile: An intestinal infection on the rise. 2010). When he initially presented to the Emergency Room at the facility, they obtained a chest x-ray which showed diffuse infiltrates in his lungs bilaterally. They also drew his labs, a complete blood count and also a comprehensive metabolic panel, both of which were all normal. They started him on a protocol antibiotic, Levaquin (levofloxacin), and admitted him due to the weakness and shortness of breath. The next day, his laboratory results showed a significant decrease in kidney function and liver function. He was immediately discontinued from all antibiotics, and he then sat that way for two days as kidney and liver function slowly resolved. While watching his labs, I questioned the Primary Care Physician(PCP) for not being on antibiotics and was met by hesitancy. I also insisted on an infectious disease(ID) consultation, who arrived the next morning. By the time his vital organs were all back to normal function, his white blood cell began elevating significantly and he complained of diarrhea. C. diff is the most important cause of infectious diarrhea in the United States. In fact, only 1% to 3% of healthy adults harbor C. diff among their normal intestinal bacteria (Clostridium difficile: An intestinal infection on the rise. 2010). The ID physician began Flagyl(Diflucan) presuming the colitis he was having was due to a gastrointestinal infection. A stool culture was obtained and tested positive for C-Diff. Within 24 hours, his abdomen became severely distended, he had a central line and a nasogastric tube, and he was on four versions of different antibiotics. Unfortunately, the infection had already taken its toll and he was intubated, then ordered for an exploratory surgery to likely remove the colon and try to save him. Our family agreed that he would not want to live that way and they removed life support. He passed shortly after extubation with family by his side. So here I sit as both a family member and also nurse practitioner-to-be, reeling in my what-ifs of the events. What if he hadn't been admitted but sent home with an oral antibiotic? Would he be up walking his dog in the early morning hours and enjoying the rest of his life like he did just days before his admission? What about if they had kept him on an oral preventative antibiotic since his antibiotic medications were discontinued so quickly? Would that have saved him? What if the PCP had been more proactive? All this and more is still going through my head. He was admitted with simple pneumonia and died as a result of complications completely unrelated. How do you think this could have been prevented? Perhaps as part of the protocol, we could prescribe prophylaxis antibiotics when discontinuing medications suddenly like this. Elderly and the young are so susceptible to common infections and avoiding simple complications would help save many of their lives if we just gave an effort to make change happen. Perhaps it was all the health professionals that we witnessed entering the room, without contact precaution equipment, and then care for my grandfather only to visit another patient without gowning or washing their hands. All we need to do is follow procedures, use precautions, and not become lazy in our efforts to care for our patients. Reference Harvard Health Publications.Harvard Men's Health Watch