Also see or reference Stevens-Johnson Syndrome. It is often seen with Sulfa reactions and also can be seen in Dilantin Toxicity and reactions to Flagyl as well. Skin sloughs, just as in a burn and if severe enough need burn care in a specialized burn unit, as you are describing. Some have died, My aged mother, with known sulfa allergy was given Bactrim DS in the nursing home the first month she was there (MMMMMMMMMboy was this a mad woman). She needed tanking and dsg changes like with burns, survived, did not have to go to the hospital, but did have subsequent scarring. There are too many to list here, but if you get into Pub Med or Medline search, you can find many good articles on this severe and sometimes fatal form of adverse drug event. The elderly are more prone, but not limited, of course. I also had a patient who developed this due to Dilantin. She was on the Psych floor, had a h*** of a time convincing the shrinks to consult IM to start systemic steroid treatment, fluids, etc.
thanks for this interesting post, & I hope what I gave helped in some way.