Sorry to be so long, we took a quick trip out of town (hill country, toobing, yea!)
That's a good location for a nurse- Hobby is located between I-45 and 288, closer to I-45. If you desire to work in the Texas Medical Center itself (north of Hobby), you would have two nice ways to get there. The TMC is a happening place. There are lots of outlying hospitals south of Hobby, too. Memorial SE (the biggest), Clear Lake Regional (it's round), and St Johns(Catholic) would be easy to get to. You could probably check on-line to see their job postings.
With no kids to consider, you could live anywhere really, since you don't need to consider school districts. You might prefer Pearland for the small-town feel. League City and Friendswood also retain some of the small town feel and are closer to the water areas if you like boating and water activities.
Hobby is surrounded by acres and acres of apartments. They will be close to his work, but noisy. Also, the surrounding are is not known as a great place to live. You should head down I-45 south (away from town) a couple of exits for housing. Perhaps Sagemont (west at the Beltway 8 exit)- it's a giant residential subdivision, or into Pasadena (east at the BW8 exit). Your husband might prefer the Clear Lake area (my area), just a few exits, further because it is home to the Johnson Space Center and Ellington Field, and he'll find lots of pilot and engineering types there. Every time a plane files over, every geek (a joke) in the neighborhood looks up to ID it- we have alot of unusual crafts r/t Ellington Field.
Have no doubt you will need a map! Houston is the 4th largest city in the nation. We have it all here, you just have to drive to get to it!
Let me know if you have more questions.