I'm assuming that you are already familiar with my beloved hometown, right? If not, I strongly urge you to take some time to come for a visit. Get to know the feel of the city, climate, geography, etc. Even though I wouldn't want to live anywhere else, I freely acknowledge that it's not everyone's cuppa tea.
is one of the best sites to explore the characteristics of different areas. Lots of great details about available properties, school districts, and other helpful information. If/when you are ready to prepare for your relo, I suggest that you rent for a while and give yourself plenty of time before making a decision to buy. Hopefully, this would prevent any nasty surprises having to deal with periodic flooding, unusual HOA restrictions, discovering that you are in a hurricane evacuation zone, unexpected tax levies from your local MUD or finding out that a builder is erecting a high-rise behind your house .... yep, that could really happen. Using a qualified Realtor is a good idea because s/he can guide you through all of the 'unique' aspects of living in my H-town.
With your level of specialty expertise, you shouldn't have any problems finding a job. If you don't already have it, CCRN certification, you may want to get one prior to your move because it would really add value to your job search. I know that CHI St. Lukes has been offering hiring bonuses for specialty areas, but there is always a need for CC nurses, so you may very well be able to negotiate relo assistance from any of the major systems. In the metro facilities - if you don't have one, you may be hired on a contingent basis - requiring you to obtain a BSN within a specified period of time.
I'd advise against relocating during our "Bikram" season (June - Oct) because triple digit temps and 90% humidity can be really challenging for newbies - LOL.