From my experience, it all depends on your family and finding a supportive employer.
I had no local family, therefore no "free" childcare, so planning for childcare costs and scheduling for school hours is essential.
Employers vary as to whether they will accomodate requests for child-friendly hours. I have never heard of any overnight childcare, so nights are out. Day shift will only work if you employ someone to get your kids to school and watch them afterwards.
I was already an RN when I became a single mom, so I can't answer your questions about nursing school
. But think long term, do you really want a paid carer looking after your kids while you are out there paying for them?
I opted to take office work and other 9-5 jobs until my son was around 14, then i went back to nursing properly, (I had done per diem only to keep my licence) and I am glad I did it that way. They only have one childhood.