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Reasons for Flu Vaccine Reluctancy



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No. 30
Old Nov 07, 2009, 12:09 AM

Default Re: Reasons for Flu Vaccine Reluctancy
Originally Posted by larryh View Post
Indigo Girl..
Short answer to your question: I don't know where you would go to find that information.
Longer answer, if I had the time and the desire, I would:
1. Contact CBS, ask for the transcripts of that particular 60 minutes, including any references, if available. They might or might not have information going back that far, but that would be where I would start. Might be able to get knowledge of what sources they got their information from. I've actually done this before, and you might be surprised what you would get. Of course, we are still talking about an show from
2. Barring that, find a good Medical Library (brick and mortar or on-line) that will let you query their indexes (Medline search or similar). Take some time researching, I would bet that 60 minutes got the information right from some article in NEJM or something like that. Its back there somewhere, probably on microfiche, hopefully scanned to computer format, but who knows?)

Would be nice if stuff from 25 to 30 years ago could all just be Googled, but that's probably going to take awhile.
Sorry I couldn't be more help!
Here is one article referencing X53, X53A from 1977.

Correlation of Laboratory Studies with Clinical Responses to A/New Jersey Influenza Vaccines
Francis A. Ennis, Ronald E. Mayner, David W. Barry, Jody E. Manischewitz, Ruth C. Dunlap, Martha W. Verbonitz, F. Marilyn Bozeman and Geoffrey C. Schild
The Journal of Infectious Diseases, Vol. 136, Supplement. Clinical Studies of Influenza Vaccines: 1976 (Dec., 1977), pp. S397-S406
(article consists of 10 pages)
Published by: The University of Chicago Press

Stable URL: http://www.jstor.org/stable/30107506

Abstract The large, uniformly performed clinical investigations with influenza A/New Jersey vaccines provided an opportunity to correlate results of laboratory tests of vaccines with human reactivity and antibody responses. These vaccines were given to large numbers of subjects under code, and significant differences in immunogenicity and reactivity were observed in unprimed individuals. A single, relatively large dose of intact virus was more immunogenic and reactive than split-virus vaccines in unprimed subjects. Differences in immunogenicity and reactivity in unprimed subjects correlated with the amount of intact virus in the vaccines (measured by column chromatography or electron microscopy) and with the amount of viral hemagglutinin in the vaccine (measured by immunodiffusion), but not with the number of chick cell-agglutinating units.
http://www.jstor.org/pss/30107506

full article requires payment of fees.
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