Question about GBM treatments? | allnurses

Question about GBM treatments?

  1. 0 I need to find out more about GBM (glioblastoma) brain tumors, and current treatments. Situation is patient has just had a GBM (primary CA) removed from occipital lobe, will undergo radiation and low-dose oral chemo. Chemo will be ongoing, scans q2mos until the tumor reappears--it is expected to grow again in approx a year, to year and a half. At THAT time, while sx is option, radiation is not. Prognosis, therefore, is not good.

    Someone mentioned that Johns Hopkins is doing something now with nano treatments....? Something that might not require a traditional "cutting" sx, but instead something....else?

    Anyone know more about this?
  2. Visit  RNsRWe profile page

    About RNsRWe

    RNsRWe has 'Enough' year(s) of experience and specializes in 'pulling patients back from The Light'. From 'Wedged between a rock and a hard place!'; Joined May '05; Posts: 10,467; Likes: 23,359.

    12 Comments so far...

  3. Visit  OCNRN63 profile page
    1
    RNsRWe likes this.
  4. Visit  RNsRWe profile page
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    Hmmm....interesting! Yes, this is where my mind was wandering. Thanks for link!
  5. Visit  OCNRN63 profile page
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    Error--sorry.
    Last edit by OCNRN63 on Nov 14, '12
  6. Visit  OCNRN63 profile page
    0
    Cancer Treatment Centers of America have a NanoKnife, but I think that's more for tumors on the liver, pancreas, GB, etc.
  7. Visit  sunbaby0811 profile page
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    Duke is doing a lot with gbm. Your patient should check w them. I have a friend w gbm and she saw them for advice but then ended up decided to be treated and followed locally. Blessings to your patient.
  8. Visit  RNsRWe profile page
    0
    Quote from sunbaby0811
    Duke is doing a lot with gbm. Your patient should check w them. I have a friend w gbm and she saw them for advice but then ended up decided to be treated and followed locally. Blessings to your patient.
    Good to know....I'm making sure pt has all the info I can find, thank you kindly!
  9. Visit  KelRN215 profile page
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    GBM has an incredibly poor prognosis no matter what. Median survival is about 12 months. Standard treatment is surgical resection followed by radiation and concomitant temozolomide. Temozolomide has actually improved survival but the prognosis is still very poor. In general, you only radiate the brain once which is why radiation will not be an option when the tumor recurs.

    I had a patient last year who was on a phase I clinical trial studying the use of a viral vector in the treatment of glioblastoma. Basically, they inject a viral vector directly into the tumor and then treat the patient with an oral antiviral (in this patient's case it was valacyclovir)... the idea is that the valacyclovir will attack the virus and will kill the tumor that is harboring the virus. In this patient's case, she died 10 months after diagnosis and she was also treated with radiation, avastin and antineoplaston at the Burzynski clinic in Houston.

    Here's a link to the viral vector study:
    Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas - Full Text View - ClinicalTrials.gov
  10. Visit  OCNRN63 profile page
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    RNsRWe: I have a friend who works in oncology @ Hopkins. I'll see what she has to offer.
  11. Visit  RNsRWe profile page
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    Thank you both for the information. I'm going to check out that link, Kel...
  12. Visit  RNsRWe profile page
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    Been reading about something called CyberKnife, in Philadelphia. Not sure if it's applicable, but it's at least something to discuss.
  13. Visit  KountryPrincess profile page
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    Great post Kel.....very informative.
  14. Visit  RNsRWe profile page
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    Quote from OCNRN63
    RNsRWe: I have a friend who works in oncology @ Hopkins. I'll see what she has to offer.
    What about nanobots @ Hopkins.....would your friend know something?


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