Where does cyclooxygenase come from?

  1. I'm sorry if this is a stupid question but I can't seem to find it.

    I know its inhibition helps release cell-mediators, but where does it come from?
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  2. 1 Comments

  3. by   JustBeachyNurse
    Try google. Quite a few scholarly references come up.

    I will even post this which was fourth in the search list:

    Two isoforms of the membrane protein COX are known: COX-1, which is constitutively expressed in most tissues, is responsible for the physiological production of prostaglandins; and COX-2, which is induced by cytokines, mitogens and endotoxins in inflammatory cells, is responsible for the elevated production of prostaglandins during inflammation.
    . Explained here: Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents. - PubMed - NCBI

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