Dec 18, '07
This link might be a little complex, but I found it very helpful:
This link has a lot of information:
Last edit by UM Review RN on Dec 18, '07
Dec 19, '07
hi, bnzhd, and welcome to allnurses!
the basic pathophysiology is that once bacteria enter the bladder, local defense mechanisms in the bladder break down and the bacteria invade the bladder mucosa and begin to multiply. the bacteria that have lodged in the mucosa cannot be eliminated by urination. inflammation also occurs; it is the general response to any bacterial invasion which results in vascular permeability. because of the vascular permeability, bacteria that have invaded the bladder mucosa are able to escape into the blood stream and this is the actual start of septicemia. once the bacteria enters the blood stream they release endotoxins and the symptoms of bacteremia are produced.
also see. . .the pathophysiology of the inflammation response on this thread: http://allnurses.com/forums/f50/hist...ct-244836.html
Last edit by Daytonite on Jan 31, '08