Isotonic, Hypotonic, and Hypertonic IV Solutions

  1. 0 Hi everyone,

    I've been reading over my texts trying to figure out why D5W 1/2 Normal Saline is HYPERtonic. I'm confused because D5W alone is isotonic and 1/2 normal saline is hypotonic .. how is it that the two of them combined is hypertonic? Help please
  2. Visit  CHovs profile page

    About CHovs

    Joined Sep '11; Posts: 7; Likes: 1.

    22 Comments so far...

  3. Visit  ScottE profile page
    0
    It's really really hard to explain, but it's all about osmotic pressure.

    http://en.wikipedia.org/wiki/Osmotic_pressure
  4. Visit  dmw2489 profile page
    0
    Quote from CHovs
    Hi everyone,

    I've been reading over my texts trying to figure out why D5W 1/2 Normal Saline is HYPERtonic. I'm confused because D5W alone is isotonic and 1/2 normal saline is hypotonic .. how is it that the two of them combined is hypertonic? Help please
    Here is the thing, dextrose in the bag is hypertonic once infused into the body becomes the solutions osmolality, d5w, if you take out the dextrose and you just have the water what kind of solution is that? its hypotonic, (water doesnt have the same osmalality as the body therefore its hypotonic), d5 and 1/2 ns is hypotonic, but once again the dextrose makes it hypertonic in the bag but once infused becomes the solutions osmolality, what i find helpful is to cover up the Dextrose and look at just the solution and see what that is, b/c that is what it will be in the pt's body.



    i made this chart above, i dont know if the link will work... but i can always e-mail it to you if it doesnt. Hope this helps explain things a little easier
  5. Visit  CHovs profile page
    0
    Thank you ! Unfortunately the chart did not work, so if you wouldn't mind e-mailing it to me I'd appreciate it my e-mail address is celeste.hovagimian@live.ca

    Thanks again
  6. Visit  dmw2489 profile page
    0
    ok its sent let me know if it opens
  7. Visit  CHovs profile page
    0
    Got it ! Thanks : )
  8. Visit  faithhopelove profile page
    0
    hello dmw2489.. is that ok if I would also like to have a copy of your chart? thank you.
  9. Visit  dmw2489 profile page
    0
    of course no problem just give me your e-mail
  10. Visit  IVRUS profile page
    1
    Quote from CHovs
    Hi everyone,

    I've been reading over my texts trying to figure out why D5W 1/2 Normal Saline is HYPERtonic. I'm confused because D5W alone is isotonic and 1/2 normal saline is hypotonic .. how is it that the two of them combined is hypertonic? Help please
    D5W has an osmolarity of 252.... And 1/2 Sodium Chloride has an osmolarity of 154... Combine, or add those two osmolarities together and you get and osmolarity that is greater than "Normal Blood Plasma" which is 290. Remember that all IVF are compared to what Normal Serum Osmolarity is. Your body want homeostasis right? When your body is in that state, your blood osmolarity will be approx 290. IV fluids which are isotonic (NS and LR) are ones that are just like blood plasma, and therefore their osmolarity may have anywhere from plus or minus 50 on either side of that 290. So, 240-340 is your isotonic range. Anything >340 is hypertonic.
    GrnTea likes this.
  11. Visit  Isabellah profile page
    0
    dmw2489, I would be very appreciative if you sent the chart to me also. My email is mrbrownbear15@yahoo.com.
  12. Visit  pebs305 profile page
    0
    Would someone mind passing it along to me as well...please???
    pebles1114@gmail.com

    Many thanks!
  13. Visit  dearluv20 profile page
    0
    Hi I would really love to get a copy of this solutions chart plz! My email address is bresm04@yahoo.com
  14. Visit  ♪♫ in my ♥ profile page
    0
    Tonicity is simply a matter of how concentrated is a solution. That is, how many particles are dissolved in it. A 0.9% solution (NS) is ISOtonic, a 0.45% solution (1/2 NS) is hyPOtonic, and 5% solution (D5) is hyPERtonic.

    Mixing D5 and 1/2 NS produces a solution that's 2.75% which itself is hyPERtonic.

    The thing is, the dextrose is quickly metabolized so, practically speaking, D5 - while hyPERtonic is the bag and at the infusion site - is hyPOtonic in the body after the dextrose gets metabolized. The 0.45% Na in the 1/2 NS moves it toward being ISO tonic but it's still hyPOtonic (effectively ending up as 1/4 NS).
    Last edit by ♪♫ in my ♥ on Oct 18, '11


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