# HELP IV Medication Safety/ Loading Dose HELP

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1. Hi all! I have a question regarding an assignment for "Math for Meds." I have the answers, which are confirmed correct via a given answer key. While, I figured out how to do the calculation, I am confused/concerned about the rational.

This involves questions of "Safe loading dose."

Pt with CHF has an order for theophylline 300 mg in 50 mL D5W over 30 minutes. Pt weighs 68kg.

The lable provided states:

It calculates out to 319.6 mg (safe loading dose) per hour

The answer key states: YES, it is a safe loading dose.

This is what I am confused/concerned about:
- the pt is supposed to get 300mg in 30 minutes....

so if I divide the 316.9 by 2 (to account for the 30 minute infusion time) I get 159.8mg

How and why is this safe? Yes 159.8mg is under 300mg (or 319.6 mg for that matter)... so they are not going to "OD" but how is it safe to not receive the 300mg (as ordered)... wouldn't this make the loading dose and/or order ineffective?

Thank you in advance! I am going to ask my professor in the morning, but this is kinda driving my mind bonkers, so I thought I would reach out to the allnurses community.

Again, thank you, I look forward to hearing back from the community.
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3. 12 Comments so far...

Is the question asking if it's safe to give a 300 mg loading dose over 30 minutes?
And the right answer is "yes"?
(Want to make sure I give you a rationale for the right thing.)
5. Ok, reread, and I think I understand.
Loading dose should be 64.7 mg/kg which ends up being about 300mg, and we like to round.
So you've got 300mg, which is a safe dose.
That has NOTHING to do with the rate or the infusion time.
So in this problem completely forget about rate and time, there's no reason to even consider time unless this question is asking if that's a safe rate of infusion.
6. the lable provided states:

it calculates out to 319.6 mg (safe loading dose) per hour

the order doesn't say anything about it being per hour. the looading dose was ordered as 300mg. you figured 316. that is why the order is safe to give. do you see it. i know i always got hung up on labeling, looks like that is what is going on here.
GrnTea and PayitForwardHolistic like this.
7. Thank you so much! For curiosities sake... why does the infusion time not matter? Why does this not affect the effectiveness/ efficiency of the med?

My thoughts clouding my understanding... for example... a pt needs 1 unit of insulin for every 150 carbs ... but the pt only take .5 units... the insulin would not be effective...therefore, it would be an unsafe dose to treat the condition.

Thanks again!
8. Like most nursing students, you're overthinking it.
The question asked if it was a safe loading DOSE (which is 300mg and is safe.)
It didn't ask if it was a safe rate (600mg/hr).
Hospice Nurse LPN likes this.
9. Quote from PayitForwardHolistic
My thoughts clouding my understanding... for example... a pt needs 1 unit of insulin for every 150 carbs ... but the pt only take .5 units... the insulin would not be effective...therefore, it would be an unsafe dose to treat the condition.
And actually there, it's not "unsafe" just possibly ineffective. Big difference. Not going to help doesn't necessarily equal going to hurt.
10. for best answer please refer to:
http://www.rxkinetics.com/theo.html
GrnTea likes this.
11. aminophylline(80% theophylline)
loading dose 6 mg/kg in d5w 50 ml infuse loading dose over 30 minutes