Zosyn over 4 hrs - page 2

by OutlawNurse86 26,998 Views | 14 Comments

At my hospital we used to infuse Zosyn (2.225, 3.375, and 4.5GM) mixed with 50mL of NS over 30 minutes. Recently our hospital has changed protocol to infuse 3.375GM with 100mL of NS over 4 hrs. At first it was just for renal... Read More


  1. 0
    I recently travelled to a hospital with the 4 hr policy in place. I questioned a pharmacist about the policy- one of his replies probably drives the policy as much as any other. It allows administration of 3 doses per day instead of 4. Since hospitals are reimbursed by diagnoses anything that cuts costs is more profitable to the hospital. As long as the treatment is as effective why not save the hospital money? By the way, we did admin over 30 minutes in the ER. The pharmacist stated they would adjust when pt was in-patient
  2. 0
    I am a nursing student finishing up my last semester in the program and I am actually doing a research project on this! These articals may help:

    Pharmacokinetics of piperacillin-tazobactam: intermittent dosing
    versus continuous infusion.

    Steady-state pharmacokinetics and pharmacodynamics of
    piperacillin/tazobactam administered by prolonged infusion in
    hospitalised patients.
  3. 0
    Quote from OutlawNurse86
    At my hospital we used to infuse Zosyn (2.225, 3.375, and 4.5GM) mixed with 50mL of NS over 30 minutes. Recently our hospital has changed protocol to infuse 3.375GM with 100mL of NS over 4 hrs. At first it was just for renal patients with off the wall BUN/Creatine levels, now it is protocol for every patient receiving Zosyn. They say that the therapeutic levels stay in the system longer. I like to verify things myself, but after consulting Almighty Google, I am having trouble finding any science behind this. It makes sense to me, but I just like seeing the data for myself. I am weird.

    Anybody heard anything about this?
    We do the same at our hospital also. I found the following research point slide,

    http://www.pharmacyonesource.com/ima...i7/PipTazo.pdf

    Hope it helps.
  4. 0
    No matter the concentration (2.225, 3.375, or 4.5GM) the order always states to give Zosyn over 30 minutes, even with renal patients. Frequency is usually Q6H or Q8H.
  5. 0
    One of my coworkers the other night had a pt that had a continous Zosyn infusion. As it wasn't my pt, I don't know all the details, but she's a new grad and asked me if I'd ever heard of that. From what I understand, it was dose of 13.5grams infused over 24 hours and then started all over again. This was a Lung Ca/Breast Ca pt with mets; however was at our facility with UTI/Sepsis and had drains everywhere.. JP for the cancer to the breast, 2 chest tubes (one on either side) a Mediport and double lumen PICC line, as well as high flow O2, Foley cath, and PCA hooked up. Really, she was probably too high acuity for our floor, however the ICU was full so we ended up with this pt.


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