This is more of a personal question but I'm also wondering for my own nursing knowledge! My mom was recently dx with htn and was prescribed chlorothiazide daily. I have given HCTZ many times but never just chlorothiazide so I don't know much about it. I've looked them up and the mechanism of action is basically identical for both...so what's the real difference?
Mar 20, '13
Annals of Internal Medicine | CHLOROTHIAZIDE AND HYDROCHLOROTHIAZIDE: A COMPARATIVE STUDY OF THEIR HYPOTENSIVE, SALURETIC AND HYPERURICEMIC ACTION*†
Most of the research on this is a good bit older since chlorothiazide had kind of fallen out of favor and hydrochlorothiazide became more popular back in the 60's. This was following research that showed hydrochlorothiazide might cause >sodium excretion with < potassium reduction (over chlorothiazide). There may be valid per pt reasons to use chlorothiazide though. I don't know anymore about it than I can see in research online - not coming into contact with chlorothiazide very often.
A lot of times, older drugs seem to come back into vogue as prescribers learn more about them and their efficacy in different areas.