anyone noticing a massive increase in angiedema in patients on lisinopril? - page 2

by Sirapples 3,729 Views | 23 Comments

Ive been a nurse for about 8 years, work in icu/ed for 3 years before that medsurg. In the past 6 months I have seen maybe 12 cases of patients requiring intubation from lisinopril reaction. all of these cases the patient came... Read More


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    I think it's the increase of usage as the standard of care for ACEI. I do think however tracking what drug and where it came from might be a good idea.
    BluegrassRN and Altra like this.
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    it's definitely worth doing some research on the matter, before it reaches a pandemonium proportion.
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    Multicenter study of patients wit... [Ann Allergy Asthma Immunol. 2008] - PubMed - NCBI

    From the study abstract:
    " ... CONCLUSION: ACEI-induced angioedema accounted for almost one-third of angioedema treated in the ED, although it remains a rare ED presentation. ..."
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    Quote from morte
    someone needs to track for generic and which one. and the source, China? or other?
    someone = FDA
    SHGR likes this.
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    I'm a long time type 1 diabetic who takes it. Most diabetics are now put on Lisinopril to prevent kidney complications.
    SHGR likes this.
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    I've been seeing more idiopathic urticaria, including all over me. Turns out I am making antibodies to my own thyroid. Did this about ten years ago, took a lot of drugs for two yrs and it went away, but it's baaa-aack. Immunology guy says its common in, ahem, older women. I already diagnosed it in two friends whose PCPs were perplexed. You have normal T3 & T4 and they have to request the anti-thyroid antibodies specifically. PIA. DH had the cough c lisinopril, ditched it and is fine. More allergies in general around, plus some sort of pulmonary weirdness...
    Hoozdo likes this.
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    Seen angioedema outpatient a couple times. Looked more scary than it turned out to be. Treated outpatient, stopped the ACEI and it resolved.

    It is pretty much a standard of care for those with T2DM to prevent kidney damage.

    It's supposed to help people. darnit.

    I wonder if there is something else going on. More people with angioedema per script for lisinopril, you think? More ppl on the ACEI? Defective product? ARBS have "essentially the same end result" but are soooo much more expensive.
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    Quote from Altra
    Multicenter study of patients wit... [Ann Allergy Asthma Immunol. 2008] - PubMed - NCBI

    From the study abstract:
    " ... CONCLUSION: ACEI-induced angioedema accounted for almost one-third of angioedema treated in the ED, although it remains a rare ED presentation. ..."
    nice but is there a rise since 2008?
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    Quote from grntea
    i've been seeing more idiopathic urticaria, including all over me.
    hmmm let's not talk about idiopathic urticaria just the mention of it... i begin to scratch uncontrollably
    VivaLasViejas likes this.
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    Quote from gitanorn
    hmmm let's not talk about idiopathic urticaria just the mention of it... i begin to scratch uncontrollably
    i was scratching my neck as i read your post it is my most common site of idiopathic urticaria!


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