Why Allergy Meds Worsen Restless Leg Syndrome Histaminergic Clinical

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    Allergy Meds make RLS Worse

    "To sort out the relationship they suspected, the researchers first gave 12 RLS patients either a true sedative or diphenhydramine, the active ingredient in many allergy medications that tames histamine and induces sleepiness. They found that while sedatives had little to no effect on RLS, diphenhydramine made the RLS as much as three to four times worse."

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    As I mentioned on this site before, diphenhydramine makes me wired. I also have severe RLS. I've taken Benadryl to try to help me sleep and it made everything worse.
    I went to an MD asking for sleep meds and he told me to take Benadryl. I explained how Benadryl makes me feel and he made me look like a drug seeker. Judgmental jerk.
    I went to my current MD who actually took the time to listen and he prescribed Ambien as well as meds for my RLS.
    I feel like a NEW person!
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  2. 13 Comments...

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    Benadryl aggravates my mostly mild RLS. For me I have found that iron supplements reduce my RLS. (I read it on the internet.) But I do notice that after I donate blood, I can be almost assured that I will have a bout of RLS.
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    I suffer from extreme allergies, restless legs syndrome, and insomnia (partially related to the first two problems). I take Ambien for sleep myself. Benadryl doesn't tame the horrific respiratory symptoms associated with my allergies, and it makes me feel drugged, which Ambien does not. Cetirizine (Zyrtec) seems to work best for my allergies, with fewer side effects than Benadryl.
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    Quote from TomLM
    Benadryl aggravates my mostly mild RLS. For me I have found that iron supplements reduce my RLS. (I read it on the internet.) But I do notice that after I donate blood, I can be almost assured that I will have a bout of RLS.
    Tom, do you really have RLS, or are you getting mild spasms from anemia??
    two different things....it would be uncommon for a male to be anemic to that point and you prob. should be checked out by/with your pcp.....my mother died last year (at 85) d/t heart damage d/t anemia....which was expressing itself in leg spasms that i missed because she had RLS as well. and post stroke with spasm.....please do get checked out
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  6. 0
    Morte, thanks for the info. My condolences on the loss of your mother.

    Restless legs run in my family (pun intended).
    My doctor says I meet the criteria for RLS. I don't really have spasms as such, my legs have a low level ache that makes me have to move them to get some relief.
    There's a (seemingly) well researched entry on wikipedia about rls. Here is the link. It includes information about the link to iron for some patients.
  7. 0
    Quote from TomLM
    Morte, thanks for the info. My condolences on the loss of your mother.

    Restless legs run in my family (pun intended).
    My doctor says I meet the criteria for RLS. I don't really have spasms as such, my legs have a low level ache that makes me have to move them to get some relief.
    There's a (seemingly) well researched entry on wikipedia about rls. Here is the link. It includes information about the link to iron for some patients.
    welcome, and thank you
    i am concerned that there is a overlapping....so to speak....when my mother would describe the restless leg issue there was no pain, i as well have had a few episodes and there is no pain, not even an ache....
    so please keep a watch on things.....and as i said it would be uncommon for a male to be anemic.....you might want to get checked for an occult bleed......and i think i best stop, before i get my post pulled...lol PLEASE TAKE CARE
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    I am surprised by the number of people that still do not believe in RLS. They think it is another syndrome 'made up' so that the pharmaceutical companies can make money.

    I'll I can say is that RLS almost ruined my life. It did affect my sleep and it did make me exhausted the next day (even though the article states that many w/ RLS do not have daytime fatigue).

    I remember as a kid listening to my dad complain about his restless legs. I remember him getting up and down trying to get comfortable during the evening when we would watch TV. I remember all of the nights that he would be up because he was so restless.
    I use to think he was kidding around. After I began suffering from it (mine started very gradually) and then was dx, I apologized to him. He laughed (and then taunted me about it though)!
  9. 0
    I have RLS for many years. Tried the soap trick, all in the mind, did'nt work.

    I read Postassium helps. I'v been taking 100mgs, if sever case take 200mgs, early evening before going to bed. IT WORKS!!!!!!!!!!!

    Enjoy your sleep.
  10. 0
    I never knew what it was, but also get severe restlessness if I take diphenhydramine. Maybe this is it.
  11. 0
    i don't have rls but i do have severe muscle spasms [charlie horse]] when i go to bed
    i take a multi vit/mineral pill in the morning, i will try the banana and see if it helps


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