Structure of Key Ebola Protein Discovered

A team led by Gaya Amarasinghe, an assistant professor in biochemistry, biophysics and molecular biology, has recently solved the structure from a key part of the Ebola protein known as VP35. VP35 interferes with the natural resistance of host cells against viral infections.

"Usually when viruses infect cells, the host immune system can fight to eventually clear the virus. But with Ebola infections, the ability of the host to mount a defense against the invading virus is lost," said Amarasinghe.
This is because the VP35 protein interferes with the host's innate immune pathways that form the first line of defense against pathogens, he said.

"The next step is to use this structure to identify and design drugs that potentially bind with VP35," he said.
If a drug that inhibits VP35 function can be discovered, then the Ebola virus could potentially be neutralized.