Re: Pandemic Flu - Thread II
Commentary from Recombinomics on an article from Nature:
Qinghai H5N1 Receptor Binding Domain Changes In Middle East Originally Posted by www.recombinomics.com/News/11190601/H5N1_RBD_Middle_East.html These polymorphisms are either linked to increases in affinity for human receptors, or have been found in human isolates, suggesting various combinations can lead to more efficient human to humans transmission.
Since all are on the Qinghai strain, recombination between these sequences, can be expected, as has been seen previous in H5N1 HA cleavage site as well as the receptor binding domain.
These co-circulating polymorphisms in Qinghai isolates in the Middle East. create additional concerns.
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