I am a new grad and have been a telemetry nurse for 3 months now. The nurses that I work with transferred from hospice, OR, nursing homes, ICU, ER, and one that worked in a pediatrician's office for 10 years! Once you are working in health care, I don't think it is that hard to transfer to another area. If you like OR I think you can safely take the job and move to other positions later on if you wish. What I hear OR nurses complain, however, is that OR nursing gets repetitive very soon, so keep that in mind. As for losing your skills, I don't think you have that many skills yet to lose. Don't get me wrong, you come out out of nursing school knowing a lot, with a lot of nursing knowledge (patho, pharm, etc) but as far as nursing skills, myself and the other new grads are finding that we are really learning them on the go as we work on the floor and get to practice them over and over again, day in and day out. When nurses were trained in hospitals, working 6 days a week in the wards during the day and having classes at night, they graduated with real nursing skills (but not a lot of knowledge). When medical and nursing research exploded and the powers to be decided that it was more important for nurses to know than to do, nursing moved to colleges and universities. Now our chance to learn skills is limited to labs and one or two days a week in a hospital. That is really not enough to learn any skills the way you need to safely and proficiently apply them in real life hospitals situations.