Infection control problems using single use vials?

It really depends on the manufacturer. We use the 10cc PF saline vials and occasionally the 30cc multi-dose vials. They are not just dust covers, but are sterile underneath the cap. Now if the cap has been removed.. then... scrub, scrub, scrub.
Doubts?
Call Hospira and ask the medical dept. yourself.
And if it is sterile underneath the cap, you can scrub with alcohol prior to drawing up fluid, but it is NOT neccessary.

You are supposed to swab the stopper even if you just unsealed it and even if it is for only one dose. This is clearly stated in my Fundementals of Nursing Text by Potter and Perry on page 739. "Not all drug manufacturers guarantee the caps of unused vials are sterile. Therefore swab seals with alcohol before preparing medication. Allowing alcohol to dry prevents needle from being coated with alcohol and mixing with medication."

We routinely swab all newly opened vials, single use or multi-use. In fact, in the ED we don't ever use what remains in the multi-dose vials on anyone else. Not only was I taught this years ago our pharmacist insists on it. It only takes a moment and it's better safe than sorry.