Burnt out syndrome,so bad I want to quit my job NOW

The unit I had been working for had undergone a major overhaul---in a matter of a year and a half, we have a new boss, AND!from a general medicine unit we are now called "Special Care Oncology Unit" Those who didnt want to be a part of this change, left, and us who decided to stay have to go thru the process of chemocertification and brave this new world of oncology. I stayed because I wanted to give it a try,and just finding out everytime I go to work that this is not for me. To make things not so rosy, there's so much cattiness, back biting, and unhappy RNs in that unit that its taking a toll on me as well. I also had been working a 12 hr shift every weekend only for the past 3 years due to child care issues, and its not helping the situation at all. Is it wise for me to leave my job and take a break-say a month, then start looking for a new nursing post? To be honest, I cant even drag myself to look for another job right now, but Im browsing here and there for job openings. In short, Im a burnt out RN and a run down mom. I would appreciate all the advise/input that I can get.
Thank you!