job offers

I am a new grad my husband is well established in his govt job cant relocate, I am not getting any offers in the area where I live St. Louis not even finding any openings. Am I crazy to consider relocating for a year or 2 to make my self more marketable , we have been married 27 years and our marriage is stable yeah the few disagreements here and there kids are grown and I manage quite well on my own always have. Some friends think I am nuts to take a job out of state 4-5 hours away I can come home on weekends advice please. I have a decent job now as a RN but am miserable I just want to do what I went to school for a PNP