propofol infusion syndrome

I have not heard of this syndrome! We use propofol routinely. How do you like the intesivist in your hospital? We have discussed using them, but are not using them at this time.
thanks,
Mymimi

We usually only see hypotension with Propofol use in our unit. However, we usually use it for intubation. Generally if a patient is a short term intubation such as 24-36hrs, we will use a propofol gtt. Any longer and we use Fentanyl/Ativan gtts

I have not heard of this syndrome as well..
This drug is routinely used in our surgical & neuro icu.

Some patients can knock out quickly with a small dose of infusion some of them are still very restless with a 100mg/hr infusion...

Thanks for the info.. will check out more on this syndrome & share with my
colleagues

I hadn't heard of it either, but I echo the sentiment that it seems extraordinarily rare! As a SICU nurse I called Diprivan "vitamin D" and loved it (in my patients!!). Quick and easy to titrate, short half life, effective sedation. Every treatment and drug has a risk/benefit profile, and I have not seen any data to convince me that this is anything other than a rarely observed phenomenon in a highly specific patient group.

At the previous ICU I worked at, we had a pt die from Propofol infusion syndrome. It's very RARE!!! Problem was the Dr never monitored pt's triglyceride level while this drug was running and pt was on high dose for increased ICP's per NeuroSurgeon. After that episode, tthe sedation policy was revamped. At the current ICU I work at(it's in the same town), we do not use propofol sedation because of the aforementioned incident.

Here is a link to the coroner's inquest into our case of Propofol infusion syndrome

http://72.14.253.104/search?q=cache:...ient=firefox-a

Wow! I've never heard of this Propofol syndrome either!! We use it a lot and I would like to learn more about it. Anyone with info in the form of an article would you please post it for all of us to benefit from,please?
Thank you!

info below from: Data Sheet
Fat overload syndrome

An impaired capacity to eliminate fat may lead to the fat overload syndrome. This may occur as a result of overdosages, but also at recommended rates of infusion, in association with a sudden change in the patient's clinical condition resulting in severe renal or hepatic impairment.
The fat overload syndrome is characterised by hyperlipaemia, fever, fat infiltration, hepatomegaly, splenomegaly, anaemia, leucopenia, thrombocytopenia, blood coagulation disorders and coma. These changes are invariably reversible on discontinuation of the fat infusion.