Re: Need some solid answers Originally Posted by tri-rn
I've never heard the Mg before K thing either. Can someone explain? Why would this aggravate a hypo-k situation? Thanks in advance

few thoughts arise from this:
1) potassium channels are inhibited by magnesium. hypomagnesemia results in increased efflux of intracellular K. the cell loses potassium which then is excreted by the kidneys, resulting in hypokalemia
2) magnesium is needed for the adequate function of the Na+/K+-ATPase pumps in the cells of the heart. a lack of it depolaries and results in tachyarrhythmias. since magnesium inhibits release of potassium, a lack of magnesium increases loss of potassium. Intracellular levels of potassium decrease and the cells depolarize, hence arrhythmias
3) roughly 42% of patients with hypokalemia also have hypomagnesemia, not responding to potassium supplementation
hope this helps some-
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