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How high have you titrated levophed?



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No. 80
Old Nov 08, 2009, 08:39 AM

Default Re: How high have you titrated levophed?
Originally Posted by Nccity2002 View Post
I am sitting here in wonder and amazement after reading everyone's post...I have been an ICU nurse for ten years in a Level one trauma center, and I have to confess I had never seen anybody on 150-300 mcg of Levophed!!! At my facility the max is 20 per policy, and if that is ineffective, the consideration of other pressors need to be evaluated. I just hope that everyone is making sure to have an written order somewhere when a physician request those out of range dosages. Remember you all worked hard for your licenses.
Our max per policy is 100mcg/min. If we need more we just write an order and increase the max dosage. Routine use levoped 40-100mcg/min in some patients. I'm in a busy level 1 trauma ICU as well. It's always been interesting how different provider groups will manage the same patient in two opposite directions.
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No. 81
Old Nov 13, 2009, 10:15 PM

Default Re: How high have you titrated levophed?
Originally Posted by meandragonbrett View Post
Our max per policy is 100mcg/min. If we need more we just write an order and increase the max dosage. Routine use levoped 40-100mcg/min in some patients. I'm in a busy level 1 trauma ICU as well. It's always been interesting how different provider groups will manage the same patient in two opposite directions.

A routine use of Levophed is 40-100 mcg/min in some patients? WOW! Where are ya'll getting this information to validate it as policy? And if you use 150 mcg/min of norepi, what is ya'lls concentration?

Our policy states a max of 30 mcg/min and if any nurse would come in my room and titrate the levo to 150 mcg/min, I would slap them silly . I have seen nurses titrate vasopressin to 0.4 instead of our policy of 0.04 units/min for vasodilatory shock...I guess they get confused with the GI hemorrhage dosing. It is interesting to see the different dosing. I am in the South at a level II trauma center
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No. 82
Old Nov 13, 2009, 10:32 PM
Updated Nov 13, 2009 at 10:38 PM by bucknangler

Default Re: How high have you titrated levophed?
Originally Posted by racing-mom4 View Post
Just out of curiosity---how high have you titrated levophed before? History, pt in with serious health history, admitted with CHF. Coded on the floor. CPR alone brings back a rhythem I come in at 7pm to find her on cpap with an et tube placed. levophed at 30, dopamine at 5, heparin at 9 and propofonal at 20. We attempt ABGs and are unsuccesful, fighting the tube and restraints, increase the propofnal and attempt art line and picc line. Succesful. B/P systolic in the 70s heart rates in the 140s. I cant go too high on the dopamine due to the heart rate, titrate up and down and can not find a balance. I take the dopamine up to 10mcg at one point. Dr insists verbally over the phone I keep titrating the levophed to get bp systolic at the 100 range. Can not be done, I call pharmacy to question just how high I can go, am told there really is no cap?? according to my drug book 30 is range. Eventually pt put on vent, lower the propofonal to try and raise bp. I eventually titrate the levophed up to 60!!! I am so uncomfortable at the 60 range I call the Dr almost in tears--told him I feel like I am treading water and not keeping my head above. FYI I called him when I hit 50 and still had systolic in the 60s. I had the pumps concurrent with 75ns behind the dopamine and levophed. These are running into her picc.
No output in over 12 hours even though almost 2.5 liters of fluids/meds combined in. Dr made aware of I&O. Only order a small dose of Lasix. Not successful. ABG's horrible! FYI patient full code and family even after 3 in depth conversations insists on full code status. I am literally going over my algorithms in the supply room in preparation. Dr tells me to tell the family this is it, this is as high as the drips can go. Pt is 38 yr old. Finally family agrees to no code status, but want to remain where we are at, leave the et tube in and leave the drips where at, but understand we will not be giving any more meds.

The patient passed away shortly after the end of my shift, I was still on the unit so I assisted. Very sad, I felt so frustrated like I should have done something but totally felt like my hands were tied. Plus just didnt know what to do anyways---I was in contact with the ER doc and he had her tele up in er so he could watch. I had contacted primary and heart dr several times through out night. There is something really freaky about seeing an art line bp of 48/43 and a heart rate of 120.

I dont really even know what I am asking for in this post---I feel like I did something wrong, like I should have been doing more, or maybe did too much with the levophed that high. BUt i just didnt know what else to do, So all you critical care nurses, feel free to educate me. I am a new ICU nurse. The learning curve is huge. I had the nursing supervisor on my back most of the night, she said i did fine but I still feel like there was something else I should have suggested to the Drs.

Sounds like you did one hell of a job. What did the monitor show rhythm wise? Obviously you are on heparin for an acute coronary syndrome? I wonder what his EF was? Systolic or Diastolic Dysfunction? Since the cardiologist signed off, I amusing he reviewed the EKG and felt that he coded for a different reason unrelated to the heart? Sounds like a hemorrhage somewhere. H&H level? Interesting case. I wouldn't be afraid of raising the dopamine because of an Increase in HR in this scenario. MAX THAT gtt OUT GIRL! After all, you are already maxed on levophed and it seems his HR is racing fast because of the actual cause and not the dopamine. FLUIDS! FLUIDS! FLUIDS! I am very shocked by the behavior of the MD. He would be written up in a heartbeat at my facility.
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No. 83
Old Nov 14, 2009, 02:24 PM

Default Re: How high have you titrated levophed?
Originally Posted by meandragonbrett View Post
Our max per policy is 100mcg/min. If we need more we just write an order and increase the max dosage. Routine use levoped 40-100mcg/min in some patients. I'm in a busy level 1 trauma ICU as well. It's always been interesting how different provider groups will manage the same patient in two opposite directions.
AFAIK we don't have a max policy on levophed. The order is routinely written (via standard computer order sets approved by our pharmacy) as "Start at _____mcg/min and titrate to (choices: MAP>____, SBP>_____)."
If you're doing a mcg/kg/minute obviously the raw mcg number without the qualifier is going to be less shocking than the rate if you're doing mcg/min. Maybe that's why some people here are waxing a bit apoplectic?
We go up when we have to and bring it down as soon as we can. And yep, people do survive (some quite well) after going through episodes where they would have died had we not kicked up the levo to what some see as nursing-license-threatening rates.
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No. 84
from caitiecait
Old Nov 14, 2009, 10:19 PM

Default Re: How high have you titrated levophed?
Originally Posted by bethem View Post
I'm only new in ICU myself and have never had an experience like yours. It sounds like you did all the right things, and you seem like an excellent ICU nurse.

The only thing I questioned was the fluid - only 2.5L in 12 hours, or 2.5L during the code? If it was over 12 hours, I wonder whether some fluid resus might have filled the tank, so to speak, giving you more to play with to achieve a higher systolic.

As to levophed, the highest rate I have seen so far is 32ml/hr of quad strength, which is 8mg in 50mL.
Wait you mean 8mg in 500ml of D5W rt??!!! When would you ever mix 8 in 50 ml?? Just curious Ive never seen that before~!
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No. 85
from caitiecait
Old Nov 14, 2009, 10:23 PM

Default Re: How high have you titrated levophed?
Was vasopressin on board?? What was this pt's CVP reading? I know this pt prolly had more problems going on than intravascular hypovolemia but I dunno if the doc should have given lasix, with a crappy BP the kidneys are not going to put out squat, I think maybe the pt needed more volume and vasopressin. But I was not there that night and it sounds like you did a good job. What was the pts history and what did they come in to the hospital for if u dont mind me asking.
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