If you haven't already, you should read through the threads in this MA forum. There are many posts by both new grads and experienced nurses that have been looking for jobs in Boston for months, even years, with no luck. The job market is very tight here. There are tons of nursing schools in and around Boston with Dec and May graduates so there is a lot of competition for very few jobs. Even PCAs aren't getting jobs at their own hospitals. When I say very few jobs, I'm referring to hospitals, nursing homes, rehabs, VA, and clinics. Also, the big hospitals in Boston will only consider new grads with a BSN.
To answer some of your questions:
*You can not work as a grad nurse in MA. I don't know of any hospitals around here that will allow you to work as a CNA with an RN license. Where I work, once our CNAs/PCAs get their license, they can not work as a PCA anymore.
*Hospitals, rehabs, VAs, clinics, nursing homes, etc, all hire new grads. The problem is, there are no jobs available. There are limited job postings and like I said before, you have a whole slew of experienced and new nurses applying for the few that are posted.
*As far as I know, you have to have experience to work in Home Health. I haven't heard of any agencies hiring new grads around here. I would advise against it anyway. You need experience to work alone for the sake of both the patient and your license.
*I'm not sure what CPLS or TB is? If you are referring to Basic Life Support (CPR/AED) and Advanced Cardiac Life Support (lethal arrhythmias, code drugs, intubation) then yes, you can get certified before graduation. You can do that through the American Heart Association. Other certifications, like specialty certs, usually require a certain amount of hours worked in that specialty.
*Now is a good time to apply... and to as many places as possible to increase your chances. If you read some of the posts here, there are people who have applied to hundreds of job postings without even one call back. Most places will not take hard copies of resumes these days. I would save your time and money sending them out.
This is probably not what you wanted to hear but it is what it is. You didn't state why you are moving to Boston, but if at all possible, consider other areas of the country as well. It's not a good situation here right now.