Timing of titer following vaccines

  1. 0
    How long are you supposed to wait between vaccination (Hep B & varicella) and drawing the titer to check for conversion? Thanks for your help.
  2. 11 Comments so far...

  3. 0
    At my hospital we wait 60 days from the 3rd Hep B shot (or booster) to draw Hep B titers. I don't know about varicella - sorry! Most people getting varicella titers drawn that I know of have never had the vaccine, so we've never had to think about any kind of timing.
  4. 0
    Thanks for the info. I wonder if you get a false positive if the titer is done sooner? My RN program requires a positive titer but only give you 2 (whole) weeks between notification of program acceptance to the time when you are supposed to have your medical paperwork in and the start of classes. Considering it is a month between varicella shots and 6 months for Hep B, unless you are already immune you are not going to meet the timeline.

    I will ask them at orientation, they must have a policy for this, I'd think
  5. 0
    I'd definitely ask at orientation. I'm sure you're not the first to run into this!
  6. 1
    For Hep B, a titre should not be done sooner than 1 to 2 months after the third/last dose.
    sauconyrunner likes this.
  7. 0
    If you're in the process of getting your immunizations, then I imagine you would be compliant with the school's policy if you submit your most current vaccination information to date. Definitely ask the school, because it's likely that if you've just recently received the immunization then you don't have to provide titers at all. I think my school's policy was that you had to provide a positive titer or show proof of immunization within the past X years- depending on the vaccine.
  8. 0
    They do still require titers, but since I submitted proof of vaccination, and I have 1 more Hep shot coming, they will defer the requirement for titers until the end of the year. Thanks for everyone's input!
  9. 0
    One more comment: I believe it is really recommended that you perform serological testing exactly 1-2 months post-completion of series because titers may fall below 10mlU/ml after that, which does NOT mean protective levels are inadequate. "anti-HBs concentrations decline over time and immunocompetent HCWs who had anti-HBs levels >10 mIU/mL 1-2 months after primary vaccination series remain protected even if their anti-HBs concentration declines to below 10 mIU/mL." Ask the Experts about Hepatitis B Vaccines - CDC experts answer Q&As
    Hep B vaccination may provide protection for >20 years, but you may be required to re-start the series just b/c you delayed serological testing after vaccination.
  10. 0
    Yes, I read that for varicella over time titers will show not immune, however if the vaccinated person is exposed they do have a sufficient immune response to protect them. I didn't realize it could happen as soon as a few months after vaccination though. Thanks
  11. 0
    6-8 weeks is what's recommended. The weird part is do titers even matter? Won't your body generate an adequate antibody response if you do get exposed to the disease?


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