roxanol in neb treatments

although hepatic first-pass metabolism is avoided, thus potentially escaping some of the gi effects, i've had pts who still get nauseous.
as long as the mso4 solution is for oral consumption (and not injectable) then adding a couple cc's of ns will suffice, as well as directly targeting the pulmonary circulation.
as long as your pt is compliant with the neb treatment, w/sufficient inspirations, then effect can be optimal, even if it is variable.

leslie

I have never had good results with morphine nebs - it doesn't seem to work as well as sl for any of my patients.

i don't care for it either, doodlemom.
absorption is too unreliable.

leslie

Roxanol in nebs is contraindicated because of the sugar and additives. The pharmacy can usually make an additive free version of MSO4 to add to nebulizer that can be really effective d/t limited side effects, when patients are really concerned about sedation this can be effective.

We've always used sterile morphine that is meant for injection - still never any good results.

I called Hospice Pharmacia about this once, because I'd also heard the absorption isn't the same. The Pharmacist told me that, in fact, it is. I have used it in COPD patients with good results. Just have the MD order the sugar-free kind.
mc3

Several years ago in Boston in a palliative care unit we regularly used IV morphine with normal saline in neb treatments. Usually used 2mg morphine from a 4mg syringe with 3 ml of saline. It worked well for lung ca patients as well as end stage COPD. MDs are just not that familiar with this use and hesitate to order it. More research is needed. I have used it in homecare hospice patients in the past couple years and it was like pulling teeth to get both the MDs and the pharmacy on board since they were unfamiliar with it.

how can absorption be the same from patient to patient?
one pt can have shallow resp where the next patient will be inspiring deeply.
the one who breathes deeply, will certainly have better absorption and so, better effect.

leslie

Very good point...