roxanol in neb treatments

nhaled opioids achieve rapid but erratic plasma drug levels. Masood and Thomas[5] demonstrated that nebulized morphine achieved peak plasma levels rapidly in all subjects (within 10 minutes) compared with oral morphine but that the variability was greater-from 10 to 30 minutes. Bioavailability was 5.5% (range, 3.2-7.8%) for delivery by inhalation and 24% (15-33%) after oral administration. A previous study had found that the bioavailability of inhaled morphine in subjects on a ventilator ranged from 9% to 35% (mean, 17%).[6]

We've always used sterile morphine that is meant for injection - still never any good results.