Medication Non-compliance

I have a patient that has CHF and was recently in hospital for CHF exacerbation and pneumonia. While in hosptial she had a Thoracentesis. I received a call from her sister today who wanted to know why this patient was on so many medications (Lasix, Aldactone, Coreg, Lanoxin, Potassium, etc). I tried to explain all medications, what they do and the importance of taking daily as ordered. The sister stated she used to be a nurse and patient was taking too many medications. Sister stated she told patient not to take medications today. The patient has a little confusion but is fairly competent. I tried again to educate on importance of taking these medications to prevent exacerbations but this did not help. I finally told sister to make an apt with MD to discuss the medications.This patient has been non-compliance in the past and on many occasions the nurse has noted +3 edema to bilateral ankles and crackles in lung fields. I informed the MD of my conversation with the sister and nurse stated she would make note and inform MD. I also told nurse that sister will be calling to make apt. I tried calling this patient's daughter but no answer. What else can I do? A nurse is going back out tomorrow to talk to the patient face to face. I have also given patient written info about medications. Any sugestions?