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Caffeine and Alzheimer's



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Jul 06, 2009 01:39 PM

Caffeine and Alzheimer's

Updated Jul 07, 2009 at 09:31 AM by Angie O'Plasty, RN

New research from the US and Japan showed that giving the caffeine equivalent of five cups of coffee a day to aged mice with symptoms of Alzheimer's reversed two signs of the disease: it reversed memory impairment and reduced the hallmark protein in the animals' blood and brains.

Here's a link to the rest of the Article:
http://www.medicalnewstoday.com/articles/156452.php

I thought that this was interesting. My mother was an avid coffee drinker who drank about 8 cups of coffee a day and still suffered with Alzheimer's. She declined rather quickly too. She was diagnosed in 2000 and died in 2002. I'm wondering if she had Alzheimer's longer than what she did. She was certainly good at hiding it if that's the case.


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21 Comments
No. 1
Old Jul 06, 2009, 08:39 PM

Default Re: Caffine and Alzheimer's
If you have to give little mice the caffiene equivilant to 5 cups how much would an average sized adult need.
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No. 2
Old Jul 06, 2009, 08:59 PM

Default Re: Caffine and Alzheimer's
unless my calcs are wrong i got 14736.8 cups day



i did it as a ratio


5 x
--- = -------------
.04375 140

5 = cups a day for rat
.0475 = weight in lbs of average lab rat (20g)
x = cups for human
140 = human weight i decided to use


5(140)=.0475x
700=.0475x - then divide both sides by .0475
and you get 14736.8


this equates to 1289470mg based on a cup having 87.5mg (the average of an instant cup 65mg and drip method 110)
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No. 3
Old Jul 06, 2009, 09:01 PM

Default Re: Caffine and Alzheimer's
Well maybe I could do half that....

With that much caffeine you'd never sleep

Seriously though at 75mg per cup that would be 1,105,237.5mg per day
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No. 4
from tishirajan
Old Jul 06, 2009, 09:12 PM

Default Re: Caffine and Alzheimer's
That is unreal! Way too much coffee for the average person I would think. Thanks for the calculations!
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No. 5
Old Jul 06, 2009, 09:17 PM

Default Re: Caffine and Alzheimer's
No problem the way they decide to word it is decieving. they make this seem like a medical break through. That much caffine would mess with your heart even if you took it in a way other then coffee (like caffine tabs)
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No. 6
Old Jul 06, 2009, 09:28 PM

Default Re: Caffine and Alzheimer's
I guess this puts my screenname into a new light.
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No. 7
Old Jul 06, 2009, 09:33 PM

Default Re: Caffine and Alzheimer's
Originally Posted by tothepointe View Post
If you have to give little mice the caffiene equivilant to 5 cups how much would an average sized adult need.
I believe 5 cups is the equivalency, meaning, the mg/Kg in mice would be equivalent to humans drinking 5 cups a day.

--

When in doubt, read the paper:

Gary W. Arendash, Takashi Mori, Chuanhai Cao, Malgorzata Mamcarz, Melissa Runfeldt, Alexander Dickson, Kavon Rezai-Zadeh, Jun Tan, Bruce A. Citron, Xiaoyang Lin, Valentina Echeverria, Huntington Potter
Caffeine Reverses Cognitive Impairment and Decreases Brain Amyloid-β Levels in Aged Alzheimer’s Disease Mice
Abstract: We have recently shown that Alzheimer’s disease (AD) transgenic mice given a moderate level of caffeine intake (the human equivalent of 5 cups of coffee per day) are protected from development of otherwise certain cognitive impairment and have decreased hippocampal amyloid-β (Aβ) levels due to suppression of both β-secretase (BACE1) and presenilin 1 (PS1)/g-secretase expression.


It states clearly that the amount given to the the mice would be as if we were to drink 5 cups of coffee a day, which is what I consider the bare minimum to maintain sufficient serum caffeine levels.

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No. 8
from tishirajan
Old Jul 06, 2009, 09:38 PM

Default Re: Caffine and Alzheimer's
Originally Posted by hypocaffeinemia View Post
I guess this puts my screenname into a new light.
LOL!
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No. 9
from arelle68
Old Jul 06, 2009, 10:09 PM

Default Re: Caffine and Alzheimer's
I have a resident who's wife brought him a cappuccino one evening. We went through all of our PRNs trying to get that man to calm down. He was wrestling with my CNAs, stripping in the dining room, setting off the door alarms. I was frightened when he pinned me in a room between the beds, and wouldn't let me out. I thought he was going to hurt me. I had never seen him act like that. NO more caffeine for my residents if I have anything to say about it.
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