Peds Dosage Question

  1. Does anyone have a Peds Drug Guide? I am in desperate need of help. Does anyone know what the safe dosage range is for Ticarcillin, Furosemide, and Cefazolin? Thanks!
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  2. 1 Comments

  3. by   Anaclaire
    This information comes from my Neonatal Medications & Nutrition: A Comprehensive Guide, 2nd Edition book. Neofax is another good medication administration book we use in the NICU. 0-7days and >7days refers to the age of the baby. I'm not a Pediatric nurse but would expect these dosages would be appropriate for babies up to 1 year old. So much with babies and children depends on their weight! Maybe someone else will have more insight if your patient is older than an infant. Good luck!

    TICARCILLIN (Ticar)
    (tye-kar-SILL-in)
    Anti-Infective: Antibiotic

    Dose

    <1.2 kg (0-4 weeks): 75 mg/kg/dose every 12 hours

    1.2-2 kg:
    • 0-7 days: 75 mg/kg/dose every 12 hours
    • >7 days: 75 mg/kg/dose every 8 hours


    >2 kg:
    • 0-7 days: 75 mg/kg/dose every 8 hours
    • >7 days: 75 mg/kg/dose every 6 hours

    *Reduce dose in severe renal and/or liver dysfunction

    Administration

    IV--Rate: Infuse over 30 minutes.

    IV--Concentration: 50 mg/ml preferred, to reduce vein irritation. Maximum: 100 mg/ml.

    IV--Compatibility: Do not admix in the same IV solution with amikacin, gentamicin, or tobramycin because ticarcillin gradually inactivates these antibiotics. Inactivation also occurs in vivo, but only in patients with severe renal dysfunction.

    IM: Reconstitue 1 gm with 2 ml sterile water or normal saline to obtain 1 gm/2.6 ml (=385 mg/ml). Use the IM route only in extreme circumstances, when IV access is not possible, and then only for as short a time as possible.
    __________________________________________________

    FUROSEMIDE (Lasix)
    (fur-OH-se-mide)
    Cardiovascular: Diruetic

    Dose

    Emergency: 1-2 mg/kg/dose as a single dose.

    Maintenance: 1-2 mg/kg/dose given daily every 12 hours. In infants <31 weeks postconceptional age, dose every 24 hours or longer to prevent accumulations to toxic serum concentrations.

    Maximum: 2 mg/kg/day in preterm infants. Use the minimum effective dose.

    *A higher oral than IV dose may be required because bioavailability is reduced when furosemide is given orally.

    Administration:

    PO: Oral suspensions of 8 mg/ml and 10 mg/ml are available. The low-alcohol-content product is preferred (Roxane: <1 percent alcohol; Hoechst-Roussel: 11.5 percent alcohol). Give with feedings to reduce GI irritation.

    IV--Rate: Infuse slowly over 1-2 minutes. Rapid IV infusion may increase ototoxic effects. Maximum: 0.5 mg/kg/minute.

    IV--Concentration: May give undiluted.

    IV--Compatibility:
    {U}Compatible with[/U]: Alprostadil, amikacin, ampicillin, bumetanide, calcium gluconate, cimetidine, dexamethasone, digoxin, epinephrine, fat emulsion intravenous, fentanyl, heparin, hydrocortisone, indomethacin, lidocaine, lorazepam, morphine, nitroglycerin, parenteral nutrition**, penicillin G potassium, potassium chloride, sodium bicarbonate, tobramycin, tolazoline.

    Incompatible with: Diazepam, dobutamine, doxapram, erythromycin, fluconazole, gentamicin, hydralazine, isoproterenol, metoclopramide, midazolam, vecuronium.

    IM: May give undiluted.

    **Drugs reported as being compatible with parenteral nutrition in published studies using test solutions may not be compatible with the particular formulation your infant is receiving. Components in neonatal parenteral nutrition are individualized based on the infant's body weight, serum electrolytes, fluid, and other nutrient requirements, making most solutions unique. Observe the solution and tubing carefully for signs of precipitation during the 24-hour infusion period when drugs are coinfused. Certain drugs may be admixed into the parenteral nutrition bag. See Driscoll and associates' review of the use of parenteral nutrition as a drug vehicle. (Driscoll DF, et al. 1991. Parenteral nutrient admixtures as drug vehicles: Theory and practice in the critical care setting. Annals of Pharmacotherapy 25(3): 276-283.


    __________________________________________________ _



    CEFAZOLIN (Ancef, Kefzol)
    (sef-A-zoe-lin)
    Anti-Infective: Antibiotic

    Dose

    <1.2 kg (0-4 weeks): 20 mg/kg/dose every 12 hours

    1.2-2 kg:
    • 0-7 days: 20 mg/kg/dose every 12 hours
    • >7 days: 20 mg/kg/dose every 12 hours


    >2 kg:
    • 0-7 days: 20 mg/kg/dose every 12 hours
    • >7 days: 20 mg/kg/dose every 8 hours

    *Reduce dose in renal impairment.

    Administration:

    IV--Rate: May infuse over 3-5 minutes, but infusion over 30 minutes is preferred.

    IV--Concentration: Maximum: 100 mg/ml.

    IM: Add sterile water or sodium chloride for injection: 2 ml to a 500 mg vial for 225 mg/ml.


    Hope this helps in some way!

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