Here are the things that help me balance family and school:
1. Really good family and extended family support. My husband and my children are on board, they know this is temporary, and "mom in school" is not the rest of our lives, but only for the next few years. My sister and my parents are local and help out to balance functions I can't get to, or stepping in to fill a family need I can't fill.
2. Planning, planning, planning. I schedule EVERYthing. Including personal time, studying, etc. I try to get all my work done during the week, so I can have a school free day on Sunday. Because I've planned my study time, I can plan family time too, so my kids know that when I'm available, I'm actually present, and not distracted.
3. Realistic expectations. I took 2 years to take my pre-reqs part time. I did very well, had a 4.0, and got into nursing school. Now, I have to adjust my grade expectations since I'm taking a full time load. First of all, taking pre-reqs at a community college made me look like a genius, because of the typical CC demographic. But now I'm in nursing school with my peers, and I'm average. I'm ok with that (and the occasional B) because the alternative is to ignore my family even more, and ruin my balance. I got into school... now I just need to pass. No DON is going to ask about my B in Fundamentals.
4. Studying: You have to figure out what works for your situation. I have trouble studying at home, even when the kids are asleep. I schedule studying out of the house. Other people do fine at home.
5. When I am discouraged, I remember that I am doing this FOR my family. The sacrifice now is going to pay off when I graduate.
Hope that helps. For reference, I have 4 children, and I'm pregnant with my 5th. That's a whole other post.