The title pretty much speaks for itself as far as my question. I've had too many patients who were on Protonix with no hx of ulcers, GERD, anything. So why?!
Quote from litepath
All of theses answers while correct do miss an important point; HCL in the stomach is there to kill bugs via low pH. These inhibitors nix the low pH and thereby give rise to bug growth. Sucralfate will bind with HCl, preventing the stress ulcers w/o raising the pH to unsafe( for the patients protection) levels.
Read "The ICU Book" by Paul Marino
While that is true, sucralfate does bind to many drugs preventing absorption which can make a dosing schedule problematic since the sucralfate is typically taken qid while protonix is taken daily or q12H.
Last edit by Nurseboy1 on Oct 9, '05
: Reason: clarification