PT,PTT,INR and coumadin, explain it all please? PT,PTT,INR and coumadin, explain it all please? | allnurses

PT,PTT,INR and coumadin, explain it all please?

  1. 2 I just need a BASIC explanation of the connection of PT,PTT,INR and coumadin. What elevated and low lab values mean, etc. For some reason this is one of those things that perplexes me.
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  2. 5 Comments

  3. Visit  whipping girl in 07 profile page
    #1 10
    PT: prothrombin time...tells you if pt's coumadin is at a therapeutic level. If it's low or normal and the patient is on coumadin, then the dose is not therapeutic and needs to be increased.
    INR: international normalized ratio...still has to do with coumadin therapeutic level. When lab runs a PT you get INR results also. 2-3 is therapeutic. If it's a lot higher, the patient probably needs some vitamin K to counteract it so he won't start bleeding all over the place.
    PTT (aPTT): (activated) partial thromboplastin time...tells you if patient on heparin is at a therapeutic level. If it's low or normal and the patient is on heparin, then the dose is not therapeutic and needs to be increased. We use a sliding scale for heparin, increasing or decreasing the dosage based on APTT results.
    Coumadin: anticoagulant that take several days to start working, so heparin is given at the same time till the coumadin level is therapeutic.
    Protamine: antidote for heparin (use is patient's APPT is sky high); works quickly.
    Vitamin K: antidote for coumadin; works slowly.
    I hope this helps you get it straight.
  4. Visit  P_RN profile page
    #2 4
    pt (prothrombin time) measures coumadin effect(warfarin).. antidote vit k

    *warfarin works s l o w l y/ vit k works s l o w l y.

    the thromboplastin (testing material) various labs used was different so the results were different lab to lab. so labs started reporting inr with the pro-time.

    the inr (international normalized ratio) is calculated with a math. formula so all results from all labs can be compared.
    .....fyi: hemophiliacs have normal pro-times.

    ptt (partial thromboplastin time) measures heparin effect. antidote is protamine.....

    *heparin works quickly/protamine works quickly
    Last edit by P_RN on Apr 12, '02
  5. Visit  cbs3143 profile page
    #3 1
    For faster reversal of an elevated PT/INR, my facility gives fresh frozen plasma as well as some vitamin K. The intracraneal hemorrhage patients or GI bleeders with elevated PT/INRs, almost always receive FFP to bring their PT/INRs back down.

    Chuck
  6. Visit  Zhakrin profile page
    #4 0
    it was explain to me as such the INR is a ration and 1 is consider the normal clotting value of a person with not medical history.

    because it a ration, a INR of 2 is explained as taking twice as long to clot as a reading of one, so they clot more slowly. the higher the INR the slower the clotting facter and high the risk of hemorrhage is. a INR is threaputic when it in the precribed range, but can be dangerous if its to high.

    This is how i keep it straight, anyway good luck.
  7. Visit  ornelamuho profile page
    #5 0
    thank you a lot!!!!

    Quote from whipping girl in 07
    PT: prothrombin time...tells you if pt's coumadin is at a therapeutic level. If it's low or normal and the patient is on coumadin, then the dose is not therapeutic and needs to be increased.
    INR: international normalized ratio...still has to do with coumadin therapeutic level. When lab runs a PT you get INR results also. 2-3 is therapeutic. If it's a lot higher, the patient probably needs some vitamin K to counteract it so he won't start bleeding all over the place.
    PTT (aPTT): (activated) partial thromboplastin time...tells you if patient on heparin is at a therapeutic level. If it's low or normal and the patient is on heparin, then the dose is not therapeutic and needs to be increased. We use a sliding scale for heparin, increasing or decreasing the dosage based on APTT results.
    Coumadin: anticoagulant that take several days to start working, so heparin is given at the same time till the coumadin level is therapeutic.
    Protamine: antidote for heparin (use is patient's APPT is sky high); works quickly.
    Vitamin K: antidote for coumadin; works slowly.
    I hope this helps you get it straight.

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