ESBL infections on the rise?

  1. 0
    Hi all,

    I live in the southeastern part of the US, and we are beginning to see more and more patients with ESBL infections- all that I know of have been of the E. Coli type.

    Are you seeing an increase in your neck of the woods? most of the data I am finding on this is coming from Great Britain- it looks like it is starting to hit us here, and will become the new MRSA.

    What do you all know about ESBL? What ABTs are you finding to be the most effective? What kind of patient teaching are you doing?

    I'd love to hear from those of you who have been dealing with this.
    Thanks!

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  2. 6 Comments...

  3. 0
    What is ESBL? Never heard of it.
  4. 0
    Quote from grace90
    What is ESBL? Never heard of it.

    Ditto. I am curious to know as well.
  5. 0
    Ive never heard of it.
  6. 0
    "Extended-spectrum beta-lactamases (ESBLs) are plasmid-mediated beta lactamases of predominantly Bush class A, so far described only in gram negative bacilli. ESBLs are capable of efficiently hydrolyzing penicillins, narrow spectrum cephalosporins, many extended-spectrum cephalosporins, the oxyimino group containing cephalosporins (cefotaxime, ceftazidime), and monobactams (aztreonam). Beta-lactamase inhibitors (clavulanic acid, sulbactam, and tazobactam) generally inhibit ESBL producing strains."

    Extended-Spectrum beta-lactamase Producing Gram Negative Bacilli

    Check out the rest of the article here.


    We don't really deal with ESBL's where I work in NICU. Fortunately most of our infections can be effectively treated with ampicillin/gentamycin/vancomycin/cefotaxime.....we do occasionally use primaxin....
  7. 0
    Quote from Baptized_By_Fire
    Hi all,

    I live in the southeastern part of the US, and we are beginning to see more and more patients with ESBL infections- all that I know of have been of the E. Coli type.

    Are you seeing an increase in your neck of the woods? most of the data I am finding on this is coming from Great Britain- it looks like it is starting to hit us here, and will become the new MRSA.

    What do you all know about ESBL? What ABTs are you finding to be the most effective? What kind of patient teaching are you doing?

    I'd love to hear from those of you who have been dealing with this.
    Thanks!
    I am in the southwest USA and am seeing it in ICU. Impimem (sp?) IV is prescribed and I have read literature, (don't remember where), that it is only effective in 50% of cases. Apparently this is a new quinolone antibiotic resistant strain. I am seeing it in people previously prescribed Levaquin over long periods of time.

    I have worked in ICU for a year and have seen about 4 cases of it, none of which had a good outcome.
  8. 0
    Quote from Hoozdo
    I am in the southwest USA and am seeing it in ICU. Impimem (sp?) IV is prescribed and I have read literature, (don't remember where), that it is only effective in 50% of cases. Apparently this is a new quinolone antibiotic resistant strain. I am seeing it in people previously prescribed Levaquin over long periods of time.

    I have worked in ICU for a year and have seen about 4 cases of it, none of which had a good outcome.
    I will ask about Levaquin use in the future. Thanks for the tip.

    Every case i have seen has at the very least ended up septic, with some reaching septic shock quickly.


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