Have you considered telling the mgr. in the #1choice that it would be in her best interest to MAKE an opening for you, and the sooner the better?
OK... seriously... sure don't know what would be the way to go here. I've been in positions like that before, and I know what a dilemma it can be ! Toss and turn, toss and turn.
If there's no telling when #1 choice will have an opening and you're intent on change, then I guess if it were ME, I'd go for #2 choice just to satisfy the need for change. I would also continue to let #1 choice know that the very first opening has YOUR name on it !
Just rambling here....sorry