I've seen 25cm PEEP, but it's pretty scary. The patient was a 23 yr old postpartum amniotic fluid embolus ARDS patient. Multiple chest tubes for pneumothoraces. Could not tolerate suctioning back in the day before closed suction systems. She survived and we were quite pleased. She still sees the doc that managed her ventilator! That was at least 28 years ago! This is how she looked some days: