You did not say, but I hope he saw a physican immediately for the lump and discolorization?
I typed malrotation and choanal stenosis into
www.google.com and many many syndromes popped up. This does not necessarily mean he has a sundrome, only that he should get a full work up at a major medical center for a possible syndrome.
Be gentle with you friend. Go slow with your information. Ask her if she wants you to look things up or to help her do searches. Be very careful and caring.