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Oh my. NEVER NEVER NEVER give nubain to a patient who is taking methadone. It causes almost instantaneous withdrawal symptoms...seizures, the whole magilla. It is tough nowadays, when patients aren't so forthcoming with their drug history, and drug testing not a mandatory thing. We had a patient recently who had a history of drug use, and didn't admit to methadone use. When her drug screen came up positive for methadone, she claimed to only "take a bite" out of her brother's methadone once in a while. The doc went ahead and ordered the nubain and she had seizures within minutes of getting the nubain. I guess the nibbles of methadone were more frequent than she cared to admit.
Our pharmacy now puts a note in all of the packaged nubain, to remind us not to give to patient on methadone.